Texas Equine Veterinary Association

250 mg/mL For intramuscular use in horses only. Brief Summary (For Full Prescribing Information, see package insert) CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Zycosan contains pentosan polysulfate sodium, a semi- synthetic polysulfated xylan. It is a pale yellow to brownish yellow, clear, sterile solution. INDICATION: For the control of clinical signs associated with osteoarthritis in horses. CONTRAINDICATIONS: Horses with hypersensitivity to pentosan polysulfate sodium or any of the inactive ingredients in Zycosan should not receive Zycosan. Do not use Zycosan concurrently with other anticoagulant drugs. Do not use in horses with clotting disorders or within 24 hours of surgical procedures (see Warnings and Precautions). WARNINGS AND PRECAUTIONS: User Safety Warnings: Not for use in humans. Keep out of reach of children. Pentosan polysulfate sodium is a weak anticoagulant. Caution should be used when administering Zycosan if you are taking an anticoagulant. In case of accidental self-injection, seek immediate medical attention. If product comes into contact with skin, rinse skin thoroughly with water and seek medical attention if needed. To obtain a Safety Data Sheet (SDS), contact Dechra at (866) 933-2472. Animal Safety Warnings and Precautions: Zycosan has been shown to prolong coagulation parameters up to 24 hours after injection, therefore caution should be used when administering this drug before or after strenuous activities (see Target Animal Safety). Due to the anticoagulant effects, this drug may exacerbate Exercise Induced Pulmonary Hemorrhage (EIPH). The concurrent use of NSAID with Zycosan ® (pentosan polysulfate sodium injection) Zycosan has not been evaluated. Due to the anticoagulant effects of Zycosan and known anticoagulant effects of some NSAIDs, caution should be used if NSAIDs are concurrently administered. Horses concurrently treated with Zycosan and NSAIDs should be monitored for hemorrhage or other clinical signs of abnormal bleeding (e.g., petechiae, ecchymosis, or epistaxis). The safety of long-term repeat use of Zycosan has not been evaluated. Pigmentary changes in the retina (pigmentary maculopathy) have been reported in human patients following long-term oral use of pentosan polysulfate sodium. It is not known if a similar finding occurs in horses. The safe use of Zycosan has not been evaluated in breeding, pregnant, or lactating horses. Other Warnings: Do not use in horses intended for human consumption. ADVERSE REACTIONS: Injection site reactions were the most frequently reported adverse reactions in the field study. Injection site reactions were associated with clinicopathology changes in some cases. Other adverse reactions reported in more than one horse were prolongation of coagulation parameters (activated partial thromboplastin time (aPTT) and prothrombin time (PT)), lethargy, behavior changes, and colic. To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Dechra at (866) 933-2472 . For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/ reportanimalae. STORAGE CONDITIONS: Store at room temperature 68-77°F (20-25°C), with excursions to 59-86°F (15-30°C). MANUFACTURED FOR: Dechra Veterinary Products 7015 College Boulevard, Suite 525 Overland Park, KS 66211 USA Approved by FDA under NADA # 141-559 Zycosan is a trademark of Dechra Limited. R 01 2023 zycosan-1-page-ad - remuda.indd 2 zycosan-1-page-ad - remuda.indd 2 8/11/2023 10:59:46 AM 8/11/2023 10:59:46 AM + + Your Partners in Equine Health All of our pharmacies are proudly PCAB-accredited. Trusted leaders in equine veterinary compounding, Precision Equine, Wedgewood, and Wickliffe Veterinary Pharmacy have saddled up and merged to bring you an even greater experience, including: Convenient & fast digital ordering platform A higher level of service & increased product availability The same high-quality compounding you know & trust, now with even more support M ad i s o n M cC u l lo c h , r i d i n g S a m Come see us at Booth #49! Order & prescribe 24/7 at Wedgewood.com

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